FORMULATION AND EVALUATION OF FLOATING TABLETS OF SALBUTAMOL SULPHATE

Abstract

Salbutamol plasma half-life is 1.6 hours and need to administer frequently for better therapeutic activity. To overcome these problems it is required to deliver the single dose for a prolonged period of time. Salbutamol shows maximum solubility at acidic pH hence required to deliver the drug in the stomach is beneficial. The objective of the present work to develop sustained release floating tablets of the Salbutamol sulphate, which were designed to extend the gastric residence time and prolongs the drug release after oral administration. Different polymers such as HPMC K15, HPMC K100M, were used in order to get the desired sustained release profile over prolonged period of time. The release and floating property was depends on the polymer type and polymer proportion. The formulation prepared with HPMC K100M has more floating time then the formulation prepared with the HPMC K15 and HPMC K4M. The retardation of the polymer is in the following order HPMC K100M> HPMC K 15 M > HPMC K4M . FTIR study shows that there is no drug polymer interaction. This study has gives the preliminary idea about the development of floating drug delivery systems of Salbutamol sulphate with the use of gas generating agent.