TOXICOLOGICAL STUDIES OF ‘VITHU RASA MEZHUGU’ IN ACUTE AND CHRONIC INFLAMMATION MODELS IN EXPERIMENTAL RATS

Abstract

The paper focusses on evaluating anti - inflammatory effect of a Siddha formulation ‘Vithu Rasa Mezhugu’ to prove its claim. The trial drug is subjected for its toxicity studies on rat models. Carrageenan induced hind paw edema model and Cotton pellet granuloma method was followed for studying anti inflammatory effect. The formulation has proved to be non toxic upto 2000 mg /kg and possessed positive anti inflammatory effect on both methods with compared to Diclofenac sodium used as standard drug.