FORMULATION & DEVELOPMENT OF CEFPODOXIME PROXETIL DISPERSIBLE TABLETS

Abstract

In present research work, dispersible tablets of Cefpodoxime proxetil were formulated by direct compression technique. Cefpodoxime proxetil is an advanced-generation, broad-spectrum cephalosporin antibiotic approved for the treatment of acute bacterial exacerbation of chronic bronchitis (AECB), group-A beta hemolytic streptococcal pharyngotonsillitis, and uncomplicated skin/skin structure infections in adult and adolescent patients. Cefpodoxime proxetil has slightly bitter taste and has poor water solubility. So in case of acute bacterial exacerbation of chronic bronchitis (AECB) group- A beta-hemolytic streptococcal pharyngotonsillitis, and uncomplicated skin/skin structure infections it require immediate release of drug from the dosage form, which make Cefpodoxime proxetil suitable candidate for dispersible tablets. In the research work, dispersible tablet for Cefpodoxime proxetil was formulated by direct compression Croscarmellose sodium, sodium starch glycollate and Crospovidone were used as a superdisintegrant. It is observed that physical parameters like hardness, thickness has significant effect on the performance of the dispersible tablet, so this parameter are critically maintained or put at their optimum level during the manufacturing of the dispersible tablets to obtain desired properties of dispersible tablets. Formulation F7 shows desired result in comparison with other formulations.