PHARMACOLOGICAL STUDY OF ANTI-DEPRESSANT LIKE ACTIVITY OF CYPERUS SCARIOSUS OIL IN MICE

Abstract

This study was planning to access the anti-depressant like activity of n-hexane extract of Cyperus scariosus oil in mice. Acute oral toxicity study was performed in mice. With two dose level at 100 mg/kg and 200 mg/kg anti-depressant activity was screened using Forced Swim Test(FST) and Tail Suspension Test(TST) in mice and result were compared with standard drug Imipramine (15 mg/kg,p.o). n-hexane extract of Cyperus scariosus oil significantly (p<0.001) reduced the immobility time in both dose level at FST and TST which is similar to standard drug imipramine. The result suggest the anti-depressant activity of n-hexane extract of Cyperus scariosus oil and may due to increase of norepinephrine level in synapses.