PIPERIDONE ANALOGS: SYNTHESIS AND THEIR DIVERSE BIOLOGICAL APPLICATIONS

Abstract

Piperidones are of particular interest due to their unique biochemical properties. They serve as precursors to the piperidine ring, which is a ubiquitous moiety in many alkaloid natural products and drug candidates. In this frame, considerable efforts have been devoted to the synthesis of position isomeric piperidones and their derivatives. The pipiridone analogs that are synthesized have been bio-assayed for their varied activity. The structure-activity relationship of the piperidones has been established. This review article describes up to date methodology for the synthesis of piperidone derivatives and their biological properties.