ANTI DIABETIC ACTIVITY OF POLYHERBAL EXTRACT ON STREPTOZOTOCIN INDUCED DIABETES IN WISTAR RATS

Abstract

Aim of Study: The present study was an attempt to investigate the effect of ethanolic of polyherbal extract on streptozotocin induced diabetes in Wistar rats. The polyherbal extract contains the plant parts are whole plant of Adiantium capillus, seeds of Astercantha longifolia, fruits of Callicarpa macrophylla, bark of Ficus benghalensis, aerial parts of Melia azedarach. Material and methods: The streptozotocin-induced diabetic rats were orally treated with glibenclamide (10mg/kg) and Polyherbal extract (100 and 200 mg/kg) to the respective treatment groups. The blood glucose level, body weight, Glycosylated hemoglobin, liver glycogen, lipid profile, Determination of antioxidant status were measured at the end of the study 21days of treatment and compared to the control. Results: Polyherbal extract and glibenclamide were found to significantly (p < 0.001) reduce the blood glucose level, Glycosylated hemoglobin, lipid profile, whereas they increased body weight, liver glycogen content and antioxidant status when compared to the diabetic control. Conclusion: It has been concluded that Polyherbal extract, in addition to the antidiabetic activity, also possess antihyperlipidemic and antioxidant activities in the streptozotocin-induced diabetic model.