A CONCISE REVIEW ON NOVEL ASPECTS OF SUPERDISINTEGRANTS

Abstract

Disintegrants (substances or mixture of substances) when added to the drug formulation it facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly. The inclusion of right disintegrant is a prerequisite requirement to get an optimum bioavailability in tablets and capsules which need rapid disintegration. The efficacy of solid dosage forms can also be improved by superdisintegrants which is achieved by decreasing the disintegration time and in turn enhances the drug dissolution rate. Superdisintegrants are croscarmellose, crospovidone and sodium starch glycolate which represent crosslinked cellulose, crosslinked polymer and a crosslinked starch respectively. The objective of this review was to provide a closer look at the functionality of superdisintegrants in promoting tablet disintegration. In recent years, more attention is to formulate not only fast dissolving and/or disintegrating tablets that are swallowed, but also orally disintegrating tablets that are intended to dissolve and/or disintegrate rapidly in the mouth. The present review describes superdisintegrants, their types, ideal properties and various methods of incorporating disintegrants, mechanism of tablet disintegration. This review comprises superdisintegrants, which provide safe and effective drug delivery with patient's compliance.