FORMULATION AND IN-VITRO EVALUATION OF MOUTH DISSOLVING TABLETS OF VALSARTAN

Abstract

Mouth dissolving tablets of Valsartan drug were prepared by using three different superdisintegrants like Cross carmellose sodium, Sodium starch glycolate and Cros-povidone. Each superdisintegrant was used in three different concentrations like 2.5 % w/w, 5 % w/w and 7.5 % w/w. Total 9 formulations were developed and optimized for nature and concentration of superdisintegrants in tablets with respective to disintegration time, wetting time, water absorption ratio and in-vitro drug release. In the present study, it was proved that the formulations containing Sodium starch glycolate have shown good in-vitro results compared to other formulations. However the formulations containing 7.5 % w/w concentration of any superdisintegrants have shown better optimum results, hence selected as best formulations in this study.