ENHANCEMENT OF SOLUBILITY OF NEVIRAPINE BY USING SOLID DISPERSION TECHNIQUE

Abstract

The present research endeavor was towards the enhancement of solubility of Nevirapine by solid dispersion method. The solid dispersions were prepared by solvent evaporation method using carrier polymers like Polyethylene Glycol 6000 and Poly vinyl pyrrolidone (k 30) in three different ratios like 1:2, 1:4 and 1:6 ratio. The solubility of pure drug and solid dispersion forms of drug were studied in two selected media i.e. pH 1.2 acid buffer and ph 6.8 phosphate buffer. The results have shown that the solid dispersion forms containing PVP- K 30 in 1:4 ratios have shown better drug solubility compared to pure drug and other solid dispersion forms.