FORMULATION AND EVALUAYION OF NIFEDIPINE LIQUID DROPPED TABLETS

Abstract

Nifedipine is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive. . Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. Therefore the present investigation was to design a formulation of Liquid dropped tablet of Nifedipine. Liquid dropped tablets of Nifedipine were formulated by drug-soluton dropping technique by direct compression method. All the formulations were evaluated for disintegration time, hardness and friability, this Superdisintegrant addition method exhibits the lowest disintegration time, hence it is ranked as the best among the methods. They were prepared by using sodium starch glycolate, Ac-di-sol and cross povidone in different concentration. All the formulations were evaluated for weight variation, hardness, friability, drug content, invitro disintegration time, wetting time, in-vitro dissolution study. Among all the formulation F5 ( cross povidone - 10%) was considered to be the best formulation, which release up to 102.94% of the drug in 60 mints.