TO ENHANCE THE SOLUBILITY OF POORLY WATER SOLUBLE DRUGS BY USING SOLID DISPERSION: A REVIEW

Abstract

Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. The solubility behaviour of drug is one of the most challenging aspects in formulation development. Improvement in the extent and rate of dissolution is highly desirable for such compounds, as this can lead to an increased and more reproducible oral bioavailability and subsequently to clinically relevant dose reduction and more reliable therapy. Thus a greater understanding of dissolution and absorption behaviour of drug with low aqueous solubility is required to successfully formulate them into more soluble and hence bioavailable drug product. Solid dispersion is generally prepared with drug which is having poor aqueous solubility and hydrophilic carrier. Polymers incorporated in solid dispersion technologies are usually hydrophilic in nature and also showing compatibility with the drug to enhance the drug solubility. The Experience with solid dispersions over the last 20-30 years indicates that this is a very fruitful approach to improving the release rate and oral bioavailability of poorly water soluble drugs .The present article reviews the basic concept about solid dispersion, various types of solid dispersion, criteria of solvent selection, the methods of preparation, characterization, their advantages, limitations, applications.