COMPARATIVE STUDY OF PLASMA FIBRINOGEN LEVEL IN STROKE PATIENTS WITH NORMAL SUBJECTS

Abstract

Cerebrovascular diseases are the major causes of disability and mortality in developed countries. According to neurologist stroke is termed as an event of “Cerebral vascular Accident” (CVA).Although the role of fibrinolytic systems have been studied in past trends there are clinical evidences that indicate that the increase in plasma fibrinogen level is associated with increased risk of prevalence of episodes of stroke. Increased activity of von- will brand factor is mainly associated with increased bleeding in the brain regions appropriately. The above mentioned factors plays a major role in vascular components as well as in higher centers of central nervous system by decreasing the blood flow inside the vascular components and in major blood vessels of our body by increasing the ischemic response. The purpose of our study is to rule out the possible role of increased plasma fibrinogen level among the stroke patients. Materials and Methods: The present study was conducted on stroke patients those who are admitted in the Stroke ward of Department of Neurology, SRMC&RI. The sample size was around 76.Among them 50where stroke patients and 26 were normal subjects .The age groups of 76 members were around 21 to 85 yrs. Plasma fibrinogen level was estimated by rapid turbid method with standardized reagents. Results were analyzed accordingly. Results:Our results showed there was a marked rise level of plasma fibrinogen among stroke patients was around 547.5 ± 167mg/dl n=50.P value < 0.001.When compared to normal subjects the value was around 326.8 ± 55mg/dl n=26 the P value < 0.001.Which is statically significant. Data represented as Mean ± SD. Conclusion: Fibrinogen is factor which is responsible for the non –traditional stroke. The increased fibrinogen level in blood may lead to excessive clumping of blood cells, causing a clot formation in the major artery, which may promote the development early stage of Stroke in old age. From our study we concluded that the serum plasma fibrinogen level is elevated in stroke patients. .