BACOPA MONNEIRA (BRAHMI) MODULATE ALTERED THYROID HORMONES IN ALUMINUM INDUCED ALZHEIMER’S LIKE RAT MODEL

Abstract

Aluminum (AL) has been recognized play an important role in the development of Alzheimer’s disease (AD). In the present study we attempt to explore the protective effect of bacopa moneeira on altered thyroid hormone activity and association with AD in rats. 100 mg /kg body weight of AlCl3 was given orally to rats for 90 days and a group of rats co-administered with 40mg/kg body weight of bacopa monneiri. Time dependent study was carried out on the 30, 60 and 90 days of treatment. The T3, T4 and FT4 were estimated. We observed that the concentration of T3 and T4 levels significantly correlates with the exposure of AL. while the B. monneiri correlates modulate to these changes on 60th and 90th day of treatment. On the basis of results it may conclude that the concentration of T3, T4 and FT4, a marker of AL induced neurodegeneration. B. monneira modulate these changes significantly.