SYNTHESIS, CHARACTERIZATION AND EVALUATION FOR ANTI-ARTHRITIC ACTIVITY OF SOME NOVEL 4-THIAZOLIDINONE DERIVATIVES

Abstract

The objective of the present work is to synthesis of N-[2-(4-substituted phenyl)-4-oxo-1,3-thiazoldine-3-yl]-2(naphthalene-2-yloxy) acetamide and evaluate for anti-arthritic activity. Based on this a new series of compounds have been planned to synthesize by reacting β-napthol, ethyl chloroacetate, hydrazinemonohydrate, ethyl alcohol and various aromatic aldehydes. The anti-arthritic activity was evaluated using In-vitro Bovine serum Albumin denaturation method and In-Vivo Formaldehyde induced arthritis in rats. In result it was found that tested drugs inhibited Protein denaturation in-vitro which are comparable with standard diclofenec . In Formaldehyde induced arthritis , tested compounds decreased the paw volume and improved haematological parameters. This result suggest the synthesized compounds posses good anti-arthritic activity. Keywords: 4-Thiazolidinone Derivatives, Bovine serum Albumin denaturation, Formaldehyde induced arthritis in rats.