FORMULATION AND IN-VITRO EVALUATION OF FLOATING MATRIX TABLETS OF CIPROFLOXACIN HCL

Abstract

Floating matrix tablets of Ciprofloxacin HCl were prepared by using two different synthetic polymers. The floating properties and in-vitro drug release properties were optimized by changing the effervescent agent and total 4 formulations were developed. The synthetic polymers used were HPMC K15M and HPMC K100M. Each polymer was used differently in combination with two different effervescent agents like CaCo3 and NaHCO3. In this study it was confirmed that the formulations containing HPMC K100M, have shown better floating properties and finally the formulation containing a combination of HPMC K100M and CaCO3, has shown better in-vitro release properties.