PHARMACOLOGICAL SCREENING OF ANTIHYPERLIPIDEMIC, ANTI-STRESS AND ANXIOLYTIC ACTIVITY OF POLYHERBAL FORMULATION IN RODENTS

Abstract

DivyaMedoharVati is a polyherbal formulation comprising of Commiphorawightii, Shilajita Sat, Terminaliachebula, Terminaliabellerica, Emblicaofficinalis, Picrorrhizakurro, Boerrhaaviadiffusa, Operculinatrupethum and many other related plant extracts, all of which in Ayurveda, are reported to promote physical and mental health, and improve defence mechanism of body. The present study was undertaken to investigate the anti-hyperlipidemic, anti-stress and anxiolytic activity of this polyherbal formulation. Methods: The extent of Anti-hyperlipidemic activity of the polyherbal formulation was assessed after drug treatment by the lipid profile evaluation in Triton-X induced obesity in adult male rats.Atorvastatin was used as the reference standard. The anti-stress activity was observed in anoxic stress tolerance and swimming endurance test models of Swiss albino mice. Aswagandha was used as the reference standard. The anxiolytic activity was estimated in Swiss albino mice using Elevated Plus Maze, and Light and Dark Box Model. Diazepam was used as the reference standard. Results: The polyherbal formulation showed significant Anti-hyperlipidemic activity by decreasing the serum Triglycerides and cholesterol levels as well as showed significant increase in HDL levels. The stress and anxiety levels were also significantly reduced. Interpretation and Conclusion: The polyherbal formulation showed significant antihyperlipidemic, antistress and anxiolytic activity.