REASSESSMENT OF NOVEL CO-PROCESSED MULTIFUNCTIONAL EXCIPIENTS

Abstract

Co-processed excipients, wherever, excipients are commingled by virtue of sub-particle level interaction have provided
an attractive tool for developing high functionality excipients. The multifold advantages offered by co-processed excipients such
as output of synergism in functionality of mortal components, diminution of company’s regulatory concern because of absence o f
chemical process during co-processing and improvement in physico-chemical properties have built up their use in the
pharmaceutical industry. The excipient industry, which bears largely comprised an extension of the food industry, has adopted the
novel usage of particle engineering and material sciences to pave the way for a Modern category of functional excipients called co
processed multifunctional excipients. The co-processing comprises the most widely explored method for the formulation of
directly compressible adjuvants because they are cost effective and can be prepared in-house based on the functionality required.
This reassessment article is in pursuance of affording elaborated information on the sources of new excipients, potential
advantages of co-processed excipients, material characteristics required for co-processing, methods of preparing various coprocessed
excipients for direct compression available in the market.