HYPOLIPIDAEMIC ACTIVITY OF Punica granatum FLOWERS ON HYDROGENATED GROUNDNUT OIL INDUCED HYPERCHOLESTEROLEMIC RATS

Abstract

The present investigation was undertaken to evaluate the hypolipidemic activity of aqueous extract of Punica
granatum flowers in hydrogenated groundnut oil induced hypercholesterolemic rats high fat diet produced a significant increase in
total cholesterol, LDL, PL, Triglycerides and decrease in HDL. Reduction in the activity of lipo protein lipase was observed.
High fat diet also decreased the levels of SOD, CAT and reduced glutathione with associated increase in lipid peroxidation.
Treatment with Punica granatum flowers (100 mg./kg b.wt./day) altered the deranged metabolic profile and was effective in
producing hypolipidemia.