EFFECT OF FORMULATION COMPONENTS ON THE IN VITRO SKIN PERMEATION OF MICROEMULSION DRUG DELIVERY SYSTEM OF PIROXICAM

Abstract

The aim of this research is to prepare , characterize and assessment of in vitro skin permeability of Piroxicam
microemulsions through excised rat skin for pain relief. physicochemical drug properties , skin thickness, or formulation have
role in drug transition from the skin surface to underlying tissues or to the systemic circulation. For this purpose, eight
formulations made from oleic acid,tween 80,labrasol and propylene glycol were used at 0.3% of piroxicam to evaluate in vitro
release through synthetic membrane and ex vivo permeation through rat skin using diffusion Franz cells. Phase diagrams indicated
more extensive microemulsion region with a rise in S/C ratio. The release percent was enhanced with decrease in the oil percent.
In permeation studies the correlation between Tlag and P with water percent was significant and indirectly. Jss of piroxicam of
ME 3 and Dapp in ME7 were 1.8 times and 42.57 times higher than those of saturated water solution of piroxicam.