IN-VITRO DRUG RELEASE STUDIES OF INSULIN LOADED EUDRAJIT RL MICROSPHERES

Abstract

The speculation of this research was to observe whether Eudrajit RL microspheres have the potential to serve as an oral
carrier for peptide drugs like insulin. Eudragit RL-100 based Insulin loaded Microspheres were prepared by quasi-emulsion
solvent diffusion method with polysorbate 20 as dispersing agent in the internal aqueous phase (IAP) and PVA/PVP as
stabilizer in the external aqueous phase. The production yield was found to be between 70-79% for SP1-SP4. In the first hour
drug release of different Microsphere formulations SP1- SP4 was noted to be 15-30%. This may be attributed to the
drug present in the pores of the Microspheres. The overall cumulative percent release for different Microsphere
formulations SP1-SP4 at the end of eight hours was found to be 61-94 %.