Main Article Content

Abstract

Buccal route is the most preferred route, which can by-pass and allow the drug directly in to systemic circulation. In the present study, buccal mucoadhesive tablets of Metoprolol succinate were prepared by using the polymers like HPMC K4M and Carbopol 974p. By using each polymer, 5 formulations were developed with varying drug : polymer ratio. With HPMC K4M, the five ratios selected were 1:1, 1:2, 1:3, 1:4 and 1:5 whereas with Carbopol 974p, the selected ratios were 1:0.25, 1:0.5, 1:0.75, 1:1 and 1:1.5. From this study it can be concluded that formulation F6 containing 1:0.25 ratio of drug : Carbopol 974p, has shown optimum bioadhesion and in vitro release properties.

Keywords

Metoprolol succinate buccal mucoadhesive bioadhesion

Article Details

How to Cite
Peetha, V. R., & P, G. R. (2013). FORMULATION AND IN VITRO EVALUATION OF BUCCAL TABLETS OF METOPROLOL SUCCINATE . International Research Journal of Pharmaceutical and Applied Sciences, 3(2), 102-111. Retrieved from https://scienztech.org/index.php/irjpas/article/view/615