ANTIDIABETIC ACTIVITY OF METHONOLIC EXTRACT OF IN STREPTOZOTOCIN INDUCED DIABETIC RATS HIBISCUS DEFLERSII

Abstract

The aim of present study was to evaluate antidiabetic activity of methanolic extract of Hibiscus deflersii (family
Malvaceae) leaves in streptozotocin induced diabetic rats. The alcoholic extract of Hibiscus deflersii was studied for antidiabetic
activity in streptozotocin induced diabetic rats by oral administration of extract 400mg/kg body weight for 15 days. The effect was
compared with oral dose of 0.5mg/kg Glibenclamide. The determination of blood glucose level by GOD-POD kit method. The
result shows the alcoholic extract of Hibiscus deflersii leaves significantly lowered the blood glucose of hyperglycemic rats. From
the toxicity study it was observed that methanolic extract of Hibiscus deflersii was nontoxic up to 5g/kg body weight and
phytochemical study showed the presence of phytosterols, flavonoids and glycosides. It is concluded that Hibiscus deflersii leaf
extract has significant antidiabetic activity, which lowered the fasting blood glucose level in Streptozotocin induced diabetic rats.