EVALUATION OF ANTI HYPERGLYCEMIC ACTIVITY OF AQUEOUS EXTRACTS OF ALOE VERA (LEAF EXTRACT), AEGLE MARMELOSA (FRUIT EXTRACT), BUTEA MONOSPERMA (FLOWER EXTRACT)

Abstract

The objective is To know whether the aqueous extracts of Aloe vera (leaf extract), Butea monosperma (flower
extract), Aegle marmelosa (fruit extract) are having Antidiabetic activity or not. To compare the hyperglycemic effect of Test
drugs with that of the Standard Glibenclamide.To compare the potency of the Test drugs with that of Standard Glibenclamide
Wistar rats of either sex were administered with alloxan (200 mg/kg/i.p/1wk).The animals under study were kept for fasting for
18hrs and they were subjected to blood glucose analysis. The rats showing FBG greater than 250 mg/dl were selected for the
study. These animals were divided into 6 groups of each 6 animals and administered the test drugs (Aloe vera (leaf extract), Butea
monosperma (Flower extract) and Aegle marmelosa (fruit extract) orally for 15 days. The blood samples were withdrawn by retroorbital
puncture after 5th, 10th and 15th day of experimentation. The blood glucose levels were estimated by enzymatic method
(Trinder’s method). From our study we could conclude that out of the three herbal extracts aloe vera had proved to be equipotent
as that of Glibenclamide. The study can be extended in formulating the poly herbal formulation which might show the synergistic
effect of the three herbal drugs..