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Abstract

Amongst the non-endocrinal actions, insulin in cardiovascular system causes positive inotropic action & reduces
peripheral vascular resistance. Due to these actions it can be useful in Congestive Heart Failure and digitalis toxicity. Glucose-
Insulin-Potassium infusion enhances left ventricular function, in patients with recent myocardial infarction as well as in patients
with chronic myocardial infarction. Besides these insulin has anti-inflammatory action, which can be used for rapid wound
healing. Insulin also keeps blood vessels in the brain healthy and is useful in Alzheimer’s Disease to improve cognitive function.
It plays an important role in growth & has an anabolic action. That is why deficiency of insulin in pregnancy causes low birth
weight of newborn. Insulin by suppressing ghrelin increases appetite. Insulin increases antiaging protein (K-lotho). Animal studies
have shown that overexpression of K-lotho extends life span. It also potentiates the cellular responses of chemotherapeutic agents
in cancer and adding intravenous insulin to standard treatment, decreases the standard doses of chemotherapeutic agents required
and treatment is less toxic also. It also promotes cell growth, cell division, migration, and inhibits apoptosis. So the non
endocrinal applications of insulin are as an adjuvant in congestive heart failure , arrhythmia, myocardial infarction, digitalis
toxicity, wound healing, neurodegenerative diseases, stroke & along with chemotherapeutic agents in cancer.

Keywords

Insulin Nonendocrinal actions Nonendocrinal uses

Article Details

How to Cite
Bansal, A., Advani, U., Sharma, N., & Z.Y , K. (2014). INSULIN: NON-ENDOCRINAL ACTIONS AND APPLICATIONS. International Research Journal of Pharmaceutical and Applied Sciences, 4(1), 52-56. Retrieved from https://scienztech.org/index.php/irjpas/article/view/641