IN-VITRO AND IN-VIVO EVALUATION OF NOVEL MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEMS-A REVIEW

Abstract

The buccal mucosa is one of the administration sites that might provide an alternative for peroral administration. Mucoadhesive buccal drug delivery systems is one of the most important novel drug delivery systems with its various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases. The delivery of drugs through the buccal mucosa has attracted much research interest over the past two decades and numerous approaches, both conventional and complex, have been developed in an attempt to deliver a variety of pharmaceutical compounds via the buccal route. Buccal drug delivery helps to bypass first- pass metabolism by allowing direct access to the systemic circulation through the internal jugular vein. The current review provides a good insight idea anatomy and nature of oral cavity, the design of appropriate in vitro and in vivo methods to evaluate the behaviour of these bioadhesive delivery systems. The development of a range of in vitro methods is outlined including disintegration/dissolution testing, in vitro mucoadhesion tests, in vitro residence time evaluation and permeability studies.