RESISTANCE PATTERN IN CLINICAL ISOLATES OF ESCHERICIA COLI AGAINST FOUR GROUPS OF ANTIBIOTICS

Abstract

Escherichia coli are associated with variety of infections in our country. The developing resistance among different
strains of Escherichia coli against different antibiotics is a serious problem all over the world. Escherichia coli are opportunistic
pathogens. It is the most common cause of urinary tract infections, neonatal meningitis and diarrhea. During the present study 50
isolates of Escherichia coli has been collected from Dr.Ziauddin Hospital Laboratory. The sensitivity pattern of these isolates to
Ciprofloxacin, Cefepime, Cefeclor, Cefexime was determined by disc diffusion method. Data was analyzed by using National
Committee for Clinical standards (NCCLS).Escherichia coli when tested against four groups of antibiotic showed resistance
against Cefepime(42%), Ciprofloxacin(64%), Cefexime(60%) and Cefeclor(52%) in hospitalized patients. Present study showed
that Cefepime is the most effective antibiotic against Escherichia coli. However, Escherichia coli has developed resistance against
traditionally used antibiotics especially Ciprofloxacin which has reduced the number of choices for physicians in prescribing
medicine.