WOUND HEALING ACTIVITY OF ETHANOLIC EXTRACT OF POLYALTHIA LONGIFOLIA LEAVES IN EXCISION WOUND MODEL IN RATS

Abstract

The present study was conducted to evaluate the wound healing effect of Polyalthia longifolia leaf extract in excision
wound model in rats. The ethanolic leaf extract of Polyalthia longifolia (5% and 10%) were topically applied and the wound
healing potential was evaluated in rats. The wound healing efficacy was studied by using excision wound model, which was
inflicted by cutting away 500 mm2 of the skin on the anterio – dorsal side of the rats. Povidone iodine ointment was used as
reference standard. Wound healing property, based on wound contraction was measured and assessed up to 14 days. The topical
application of ethanolic leaf extract of Polyalthia longifolia (5% and 10%) had promoted wound healing in rats. There was
significant contraction of wound observed with topical application of ethanolic leaf extract at both doses of Polyalthia longifolia
in rats. Further phytochemical studies are required to isolate the active compounds responsible for these pharmacological actions.