HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CAULIFLOWER LEAVES AGAINST METHOTREXATE INDUCED TOXICITY IN ALBINO RATS

Abstract

he main purpose of the present study was to evaluate the hepatoprotective activity of ethanolic extract of cauliflower leaves against a rat model of Methotrexate induced hepatotoxicity. In this study the hepatoprotective activity of ethanolic extract of cauliflower leaves (EECL) was determined by estimating the serum parameters like AST, ALT, ALP, bilirubin, cholesterol, triglycerides and total serum proteins. The preliminary pytochemical studies revealed the presence of phytoconstituents like alkaloids, flavonoids, steroids, carbohydrates, proteins, tannins, glycosides, saponins, thiols, phenols, triterpenoids, and purins. Silymarin and EELC 200 and 400 mg/kg when administered to rats exhibited protection against Methotrexate induced hepatotoxicity as manifested by the reduction in toxin mediated rise in serum enzymes (AST, ALT, ALP, bilirubin, cholesterol and triglycerides) and increased TP levels. The histopathological studies also revelaed the preservation of liver integrity in treated groups.