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Abstract
The present study has been aimed at developing a compression coated tablets of Mesalamine with a view of minimizing the drug release in the physiological environment of stomach and small intestine and to ensure maximum drug release in the physiological environment of colon with an improved patient compliance, least side effects, better drug therapy and all aspects of an ideal drug delivery system. Mesalamine is one of the most popular drug used in the treatment of Inflammatory Bowel Disease (IBD). Here direct compression method was used for the preparation of Mesalamine core tablets and the Compression coating technique was used for coating of core tablets. Guargum alone and in the combination with HPMCK4M was used in the coating formulations. All the formulations were evaluated for the hardness, friability, thickness, weight variation, drug content, and in vitro drug release studies. In vitro drug release studies have in presence and absence of rat caecal content shown that guar gum in the combination with HPMC K4M is promising system for colon targeting
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