FORMULATION AND EVALUATION OF NIFEDIPINE BUCCAL TABLETS

Abstract

The buccal mucoadhesive tablets of nifedipine were fabricated with objective of avoiding first pass metabolism and prolonging duration of action. The mucoadhesive polymers used in formulations were Carbopol (cp934), Hydroxyl Propyl methyl Cellulose (HPMCE15), Sodium Carboxy Methyl Cellulose (NaCMC). These formulations were characterized for physiochemical parameters, in vitro bioadhesive strength, swelling index, In vitro drug release, and in vitro drug permeation. The modified physical balance assembly was used to measure the bioadhesive strength of tablets with fresh sheep buccal mucosa as a model tissue. The best mucoadhesive performance and in vitro drug release profile were exhibited by the tablet contain Na CMC, HPMC E15 and Nifedipine in the ratio of 1:1.