Evaluation of antihyperlipidemic activity of polyherbal capsules

Abstract

Hypercholesterolemia is one of the dreadful conditions that coexist in almost all the heart and endocrine-related dysfunctions. Simply elevated cholesterol levels in the blood is termed as hypercholesterolemia. Hyperlipidemia is also a synonym term and used to define elevated lipid levels. It affects almost all human beings in the world currently because of the changes in the food and living habits of the people. Most works proved those chemical constituents are antioxidants that demonstrate that the assertion that the oxidation is the main problem in causing the hyperlipidemia. So, in this research, antioxidant herbs like Psidium guava, Tephrosia and Moringa are used to prepare a gel that targets the fat deposits it the body and investigate for the antihyperlipidemic property. Herbal microspheres were prepared using the extracts of Tephrosia, Moringa and Psidium, which are incorporated into the sodium alginate and calcium carbonate. These microspheres were tested for their hyperlipidemic activity along with the extracts as such, and the results showed the microspheres showing better activity compared to the extracts compared to the standard drug atorvastatin.